Amphotericin

Amphotericin B is an antifungal medication that fights infections caused by fungus. It is used to treat serious, life-threatening fungal infections. It is not for use in treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina.

Introduction

Generic name: Amphotericin B

Brand names: Fungizone, Fungizone For Tissue Culture, Amphocin

Dosage form: intravenous powder for injection (50 mg)

Drug class: Polyenes

Uses

Severe fungal infections

Kala-azar

Benefits

Fungizone 50mg Injection works by killing the fungi which can cause serious infections. It is given by a doctor or nurse and should not be self-administered.

It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the fungi and yeast causing the infection are killed and do not become resistant.

Direction for use

  • Amphotericin B is injected into a vein through an IV. A healthcare provider will give you this injection.

  • The medicine must be given slowly through an IV infusion, and can take from 2 to 6 hours to complete.

  • Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when amphotericin B is injected.

  • Amphotericin B may need to be given for up to several weeks or months, depending on the infection being treated.

  • While receiving amphotericin B, you may need frequent blood tests.

How it works?

Fungizone 50mg Injection is an antifungal medication. It kills fungi by destroying the fungal cell membrane.

Side effects

Amphotericin B may cause serious side effects. Call your doctor at once if you have:

  • Pale skin, easy bruising

  • Blood in your stools

  • A light-headed feeling, like you might pass out

  • Seizure (convulsions)

  • Jaundice (yellowing of the skin or eyes)

  • Build-up of fluid in your lungs–anxiety, sweating, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate

  • Signs of a kidney problem-little or no urination painful or difficult urination swelling in your feet or ankles feeling tired or short of breath

  • Low potassium-confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling

  • Signs of new infection-fever, chills, flu symptoms, mouth and throat ulcers, rapid and shallow breathing.

Common side effects of amphotericin B may include:

  • Nausea, vomiting, stomach pain, diarrhea

  • Upset stomach, loss of appetite

  • Muscle or joint pain

  • Headache, ringing in your ears

  • Pain, bruising, or swelling where the medicine was injected

  • Weight loss

  • Flushing (warmth, redness, or tingly feeling).

Warnings

  • Amphotericin B is for serious, life-threatening fungal infections. It is not for use in treating a minor fungal infection (yeast infection) of the mouth, esophagus, or vagina.

  • Do not use amphotericin B in larger amounts than recommended. An overdose can cause death.

What drugs will affect amphotericin B?

Other drugs may interact with amphotericin B, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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